官方給的解決方式：
Fix For Running Wolfenstein II: The New Colossus At 4K：
1.Navigate to where you installed the game. By default, it will be “\steam\steamapps\common\Wolfenstein.II.The.New.Colossus”. Your drive location may vary, but the install path will be the same.
2.Once there, locate the executable for the game.
3.Right click on it and go to properties -> compatibility -> and select the option “Override high DPI scaling behavior. Scaling performed by:”
4.Change it to “Application” and hit Ok.

不過這樣做了之後畫面會被壓縮然後上下留黑邊...
但最少可以正常運行全螢幕不用再開無邊框視窗模式.