The Microsoft Windows 10 20H2 cumulative update, KB5001649, is unable to be updated.
Error Message: 0x80070541.

The users that need and want to install the update have to download the standalone installer from Microsoft update catalogue.
The users MAY PROBABLY need to use MediaCreationTool to Build a update installer in order to make a fresh Windows Build if the windows keeps popping up the error message 0x80070541.

however, the progress of update will take a long time.
furthermore, the microsoft recommends that the update should only be installed on the computers which occur an issue of some BSOD with printers.

Take the risk of your own.
I am irresponsible for any unexpected damage.