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allen2002
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加入日期: Jan 2002
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Rosetta (隨便亂翻 ..... )
是一套由華盛頓大學發展出的軟體, 是兩個軟體元素的結合。Rosetta ab initio(ab initio 是拉丁文, from the beginning 之義, 從最初開始) 從蛋白質其胺基酸的線性序列, 來預測摺疊的蛋白質的 3D 結構。許多應用 ab intio 理論的軟體工具已發展出來, 來加速蛋白質結構的預測。Rosetta 結合了 Rosetta ab initio 結構預測的方法, 以及以核磁共振做快速骨架結構測定的實驗數據。Rosetta Design 是一個有用的工具, 在特定蛋白質結構的胺基酸序列是好的時候, 來創造較好的蛋白質。他也可用於加強蛋白質穩定性, 及從自然界原有的蛋白質, 創造替代的胺基酸序列。

原文如下
Rosetta, a software package developed at the University of Washington, is a combination of two software elements. Rosetta ab initio predicts the three-dimensional structure of a folded protein from its linear sequence of amino acids. Numerous software tools around the ab initio concept have also been created that facilitate protein structure prediction. Rosetta combines the Rosetta ab initio structure prediction method with Nuclear Magnetic Resonance (NMR) experimental data for rapid backbone structure determination. Rosetta Design is a useful tool in creating better proteins by determining amino acid sequences that are good for a particular protein structure. It can also be used to enhance protein stability and create alternative sequences for naturally occurring proteins.
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舊 2005-01-09, 04:14 PM #396
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